I was kind of hoping that would help me narrow down which 'path' to start work on, but the most popular is pretty handily Lisa...whom I feel needs the biggest revision to work. Having a setting where the only odd things are Lisa, Victoria and a handful of other very secretive super humans just seems really lacking next to the other settings to me.
I'm thinking it'll be an alternate take on Lisa's setting - genetic engineering got a little bit more crazy, so there are human hybrids/splices though the 'augmented' like Lisa and Victoria are still really rare. More super animals and stuff running around so that it's at least a bit more "weird"... it'd give the other gals something to do here and there.
I think all the settings will be reworked a bit so that there's more for the characters to do and the player to choose from, but yeah I think Lisa's will be the most extreme makeover so to speak. Everyone will have either their established history being a "broad strokes" kind of thing or the CYOA crossover will actually be placed further ahead than I've written to thus far.
In one way it's annoying that they're so close, but I suppose on the other hand that tells me there isn't a course that's going to be widely avoided by readers, so there's that at least.
I kind of wonder if the Lisa bias is partly because I've already detailed the basic manner she would have a 'become the most powerful being in that particular multiverse' path. I actually decided each girl will get one such path, but what that means for everyone else varies wildly. It'll also require a big-jerk moment of selling out the other girls or even populations to benefit the chosen gal.